Quantitative Analysis of Coronary Endothelial Function with Generator-produced Rubidium- 82 Pet -comparison with Oxygen 15-labeled Water Pet
نویسندگان
چکیده
Purpose Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82 Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82 Rb PET and ii) compare the results with those measured using 15 O-water PET. Methods MBF was assessed at rest and during CPT with 82 Rb and 15 O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest.
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Positron emission tomography (PET) centers without cyclotrons use generator-produced rubidium-82 (82Rb) for assessment of myocardial perfusion. The aim of the present study was to determine whether myocardial blood flow could be assessed quantitatively with 82Rb and PET. Because the myocardial extraction fraction of 82Rb varies inversely and nonlinearly with flow and cannot be measured convenie...
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